A middle aged old man, with chronic renal failure is

Written By Unknown on Thursday, 10 November 2011 | 07:08

A middle aged old man, with chronic renal failure is diagnosed to have sputum positive pulmonary tuberculosis. His creatinine clearance is 25ml/min. All of the following drugs need modification in doses except.


1. Isoniazid


2. Streptomycin


3. Rifampicin


4. Ethambutol.


Ans 3 


Rifampin has hepatic metabolism, Isoniazid has hepatic metabolism but dose ¯ needed in mild to moderate renal failure. Streptomycin & ethambutol have RENAL metabolism.

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